NeuroinflammationSeptember 2025
MIF in Neurodegeneration: Systematic Review Confirms Central Role in MS, ALS, and Alzheimer's
A systematic review in Journal of Neuroinflammation analyzes over 120 studies linking MIF (Macrophage Migration Inhibitory Factor) to the progression of neurodegenerative diseases. The MIF/CD74/NF-kB axis emerges as a common cascade in MS, ALS, and Alzheimer's, with growing evidence that blocking MIF reduces neuroinflammation and neuronal death.
JFInnova Perspective
This review validates JFInnova's strategy of targeting a single molecule (CD74) with multi-disease relevance. Our pipeline already covers MS, ALS, and brain metastasis — and the MIF/CD74 axis in Alzheimer's represents a potential fourth indication.
References
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MIF contribution to progressive brain diseases
Journal of Neuroinflammation · 2024
MIF neurodegeneration MS ALS Alzheimer NF-kB