Target ValidationApril 2026
Swiss Study Identifies Microglial CD74 as Primary Driver of MS Disability
Researchers at the University of Zurich have published landmark single-nucleus RNA sequencing data demonstrating that CD74+ microglial density correlates directly with progressive disability accumulation in MS lesions.
JFInnova Perspective
While the academic community confirms the target, JFInnova already holds a patent on JFIN-0001 — a de novo VHH nanobody designed to block the MIF/CD74 axis with surgical precision.
References
1
MIF contribution to progressive brain diseases
Journal of Neuroinflammation · 2024
CD74 microglial density MS